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Top 5 Liquid Herbal & Nutraceutical OTC Supplements in the USA (2025) — Subscription Picks for Calmer Dogs: Honest Paws Calm CBD Oil, Pet Releaf Hemp Oil 330, Bailey's CBD Pet Tincture, NaturPet Stress & Anxiety, Omega Alpha E-Z Rest

Published on Thursday, August 21, 2025

Liquid herbal and nutraceutical OTC formulations offer high-bioavailability calming support using botanicals like valerian, passionflower, and hemp-derived CBD where permitted. Subscriptions add convenience and cost control by delivering adjustable dosing options, flavor choices that improve palatability, and steady replenishment for multi-dog households. In the American market, consumers increasingly prefer products with transparent third-party lab results, clear dosing per weight, and veterinarian-friendly ingredient profiles. Buyers also prioritize products that comply with Health United States rules, list full ingredient disclosures, and provide flexible subscription management for seasonal or event-driven use such as thunderstorms, fireworks, or travel.

Top Picks Summary

1. Best Everyday Calm — Subscription-ready

2. Best High-Potency Hemp — Subscription

3. Best Value CBD Tincture — Subscription-ready

4. Best Herbal Calmer — Subscription-friendly

5. Best Vet-Formulated Sleep Aid — Subscription-ready

Top Picks Summary

  1. Honest Paws Calm CBD Oil
  2. Pet Releaf Hemp Oil 330
  3. Bailey's CBD Pet Tincture
  4. NaturPet Stress & Anxiety
  5. Omega Alpha E-Z Rest
1
BEST EVERYDAY CALM — SUBSCRIPTION-READY

Honest Paws Calm CBD Oil

Honest Paws
🏠 Local Product

Honest Paws Calm CBD Oil is positioned as a market-leading, consumer-friendly CBD calming tincture that combines hemp-derived cannabinoids with palatable flavoring and clear third‑party lab testing, making it attractive for subscription buyers who want predictable recurring delivery. Its strong direct-to-consumer marketing and flexible subscription discounts deliver higher customer retention and lifetime value compared with smaller niche brands, while its blended formula competes with single-ingredient high‑potency oils by offering ease of use and broad appeal.

4.3
★★★★☆

  • Fast-acting calm

  • Broad-spectrum CBD

  • Fast-acting calm

  • Broad-spectrum CBD

Review Summary

84%

"Users commonly report reduced anxiety and calmer behavior in dogs after continued use, though results vary by dose and pet and some find it pricey. Long-term users praise its consistency and palatability but note occasional lack of effect in a minority of pets."

  • Pet-approved flavor

  • Broad-spectrum CBD tincture formulated for routine calming support in dogs and cats.

  • Pet-approved flavor

  • Broad-spectrum CBD tincture formulated for routine calming support in dogs and cats.

Increased Safety & Security

Time-Saving Convenience

Honest Paws Calm CBD Oil is positioned as a market-leading, consumer-friendly CBD calming tincture that combines hemp-derived cannabinoids with palatable flavoring and clear third‑party lab testing, making it attractive for subscription buyers who want predictable recurring delivery. Its strong direct-to-consumer marketing and flexible subscription discounts deliver higher customer retention and lifetime value compared with smaller niche brands, while its blended formula competes with single-ingredient high‑potency oils by offering ease of use and broad appeal.

  • Fast-acting calm

  • Broad-spectrum CBD

  • Pet-approved flavor

  • Broad-spectrum CBD tincture formulated for routine calming support in dogs and cats.

  • Dropper delivery allows easy, incremental dosing tailored to pet size.

  • Fast-acting calm

  • Broad-spectrum CBD

  • Pet-approved flavor

  • Broad-spectrum CBD tincture formulated for routine calming support in dogs and cats.

  • Dropper delivery allows easy, incremental dosing tailored to pet size.

Order Now

$40-70 USD

2
BEST HIGH-POTENCY HEMP — SUBSCRIPTION

Pet Releaf Hemp Oil 330

Pet Releaf
🏠 Local Product

Pet Releaf Hemp Oil 330 stands out for potency and value — a high‑concentration, full‑spectrum hemp oil aimed at pet owners who prefer a straightforward, strength‑focused product and want savings through recurring shipments. Financially it competes by offering higher CBD per milliliter than many flavored market leaders, giving cost‑conscious subscribers a technical advantage in dose control versus more diluted competitor tinctures.

4.6
★★★★☆

  • High-potency relief

  • CO2-extracted purity

  • High-potency relief

  • CO2-extracted purity

Review Summary

90%

"Most long-term users praise the product for noticeable improvements in pain, mobility, and stress with a high perceived quality and potency; a few cite the strong hemp taste and premium price. Repeat buyers often report reliable, sustained benefits for chronic issues."

  • Earthy hemp aroma

  • High-concentration full-spectrum hemp oil providing elevated CBD per millilitre for larger or chronic-use pets.

  • Earthy hemp aroma

  • High-concentration full-spectrum hemp oil providing elevated CBD per millilitre for larger or chronic-use pets.

Increased Safety & Security

Pet Releaf Hemp Oil 330 stands out for potency and value — a high‑concentration, full‑spectrum hemp oil aimed at pet owners who prefer a straightforward, strength‑focused product and want savings through recurring shipments. Financially it competes by offering higher CBD per milliliter than many flavored market leaders, giving cost‑conscious subscribers a technical advantage in dose control versus more diluted competitor tinctures.

  • High-potency relief

  • CO2-extracted purity

  • Earthy hemp aroma

  • High-concentration full-spectrum hemp oil providing elevated CBD per millilitre for larger or chronic-use pets.

  • Whole-plant extract that retains minor cannabinoids and terpenes for entourage effect.

  • High-potency relief

  • CO2-extracted purity

  • Earthy hemp aroma

  • High-concentration full-spectrum hemp oil providing elevated CBD per millilitre for larger or chronic-use pets.

  • Whole-plant extract that retains minor cannabinoids and terpenes for entourage effect.

Order Now

$80-140 USD

3
BEST VALUE CBD TINCTURE — SUBSCRIPTION-READY

Bailey's CBD Pet Tincture

Bailey's CBD
🏠 Local Product

Bailey's CBD Pet Tincture targets pet owners seeking a clean, no‑nonsense tincture with emphasis on simple ingredient lists and approachable price points, making it an easy entry product for subscription trials. It balances competitiveness between premium brands and budget options by offering perceived quality with subscription incentives, helping it attract repeat customers who want CBD benefits without the higher price of some market leaders.

4
★★★★☆

  • Easy dropper dosing

  • Third-party tested

  • Easy dropper dosing

  • Third-party tested

Review Summary

76%

"Many purchasers report solid calming and mobility benefits after repeated use, though a notable segment finds effects inconsistent between pets. Overall feedback highlights good value for the price but variable potency across individuals."

  • Chicken-flavored cheer

  • Affordable CBD tincture available in multiple strengths to fit different pet sizes and budgets.

  • Chicken-flavored cheer

  • Affordable CBD tincture available in multiple strengths to fit different pet sizes and budgets.

Increased Safety & Security

Time-Saving Convenience

Bailey's CBD Pet Tincture targets pet owners seeking a clean, no‑nonsense tincture with emphasis on simple ingredient lists and approachable price points, making it an easy entry product for subscription trials. It balances competitiveness between premium brands and budget options by offering perceived quality with subscription incentives, helping it attract repeat customers who want CBD benefits without the higher price of some market leaders.

  • Easy dropper dosing

  • Third-party tested

  • Chicken-flavored cheer

  • Affordable CBD tincture available in multiple strengths to fit different pet sizes and budgets.

  • Flavoured formulas improve palatability and make daily dosing easier.

  • Easy dropper dosing

  • Third-party tested

  • Chicken-flavored cheer

  • Affordable CBD tincture available in multiple strengths to fit different pet sizes and budgets.

  • Flavoured formulas improve palatability and make daily dosing easier.

Order Now

$30-60 USD

4
BEST HERBAL CALMER — SUBSCRIPTION-FRIENDLY

NaturPet Stress & Anxiety

NaturPet
🏠 Local Product

NaturPet Stress & Anxiety is a non‑CBD herbal liquid supplement that leverages time‑tested botanicals and nutraceutical ingredients to provide an over‑the‑counter alternative for owners avoiding cannabinoids; this reduces regulatory friction and broadens subscription availability. Technically and financially it is attractive to pet parents seeking lower‑cost, multi‑ingredient solutions compared with CBD oils, and it occupies a distinct niche alongside veterinary‑grade products for consumers focused on herbal approaches.

3.7
★★★☆☆

  • Herbal botanical blend

  • Vet-friendly formula

  • Herbal botanical blend

  • Vet-friendly formula

Review Summary

72%

"Reviews are mixed: some owners see moderate reductions in stress after regular dosing, while others report little to no change. Long-term users appreciate the natural ingredient list but often say results are mild compared with stronger prescription options."

  • Soothing lavender hint

  • Botanical liquid blend using traditional calming herbs to support stress and situational anxiety.

  • Soothing lavender hint

  • Botanical liquid blend using traditional calming herbs to support stress and situational anxiety.

Increased Safety & Security

Time-Saving Convenience

NaturPet Stress & Anxiety is a non‑CBD herbal liquid supplement that leverages time‑tested botanicals and nutraceutical ingredients to provide an over‑the‑counter alternative for owners avoiding cannabinoids; this reduces regulatory friction and broadens subscription availability. Technically and financially it is attractive to pet parents seeking lower‑cost, multi‑ingredient solutions compared with CBD oils, and it occupies a distinct niche alongside veterinary‑grade products for consumers focused on herbal approaches.

  • Herbal botanical blend

  • Vet-friendly formula

  • Soothing lavender hint

  • Botanical liquid blend using traditional calming herbs to support stress and situational anxiety.

  • Alcohol-free glycerin or water-based formulation for sensitive pets and easy administration.

  • Herbal botanical blend

  • Vet-friendly formula

  • Soothing lavender hint

  • Botanical liquid blend using traditional calming herbs to support stress and situational anxiety.

  • Alcohol-free glycerin or water-based formulation for sensitive pets and easy administration.

Order Now

$20-45 USD

5
BEST VET-FORMULATED SLEEP AID — SUBSCRIPTION-READY

Omega Alpha E-Z Rest

Omega Alpha

Omega Alpha E-Z Rest is a veterinary‑grade, clinician‑oriented liquid supplement from an Australian manufacturer, designed for rigorous formulation and consistency — characteristics that justify its premium pricing for subscription buyers who prioritize clinical oversight. Compared with consumer CBD and herbal OTC options in this list, Omega Alpha differentiates on technical rigor and vet adoption, offering a higher‑margin, professionally positioned alternative for practices and informed pet owners.

4.1
★★★★☆

  • Clinician-grade calm

  • Quick bedtime support

  • Clinician-grade calm

  • Quick bedtime support

Review Summary

81%

"Veterinary-form users generally report reliable short-term calming and improved sleep patterns in anxious pets with repeated dosing, though some find the effect modest. Repeat buyers value the professional formulation and consistent results for situational anxiety."

  • Chamomile scent note

  • Veterinary-formulated liquid supplement targeting nighttime rest and relaxation.

  • Chamomile scent note

  • Veterinary-formulated liquid supplement targeting nighttime rest and relaxation.

Increased Safety & Security

Time-Saving Convenience

Omega Alpha E-Z Rest is a veterinary‑grade, clinician‑oriented liquid supplement from an Australian manufacturer, designed for rigorous formulation and consistency — characteristics that justify its premium pricing for subscription buyers who prioritize clinical oversight. Compared with consumer CBD and herbal OTC options in this list, Omega Alpha differentiates on technical rigor and vet adoption, offering a higher‑margin, professionally positioned alternative for practices and informed pet owners.

  • Clinician-grade calm

  • Quick bedtime support

  • Chamomile scent note

  • Veterinary-formulated liquid supplement targeting nighttime rest and relaxation.

  • Contains targeted nutraceuticals in a palatable base for simple dosing before bedtime.

  • Clinician-grade calm

  • Quick bedtime support

  • Chamomile scent note

  • Veterinary-formulated liquid supplement targeting nighttime rest and relaxation.

  • Contains targeted nutraceuticals in a palatable base for simple dosing before bedtime.

Order Now

$30-60 USD

What the Research and Veterinary Guidance Say

Scientific evidence for calming botanicals and nutraceuticals is growing but varies by ingredient and species. Controlled trials, veterinary studies, and preclinical research support certain ingredients for stress reduction or behavior support, while others have promising but limited data. Liquids and tinctures can offer faster absorption and fine-tuned dosing, which is helpful when scaling by a dog’s weight. Always combine published evidence with your veterinarian’s assessment, product quality markers, and local regulatory status before starting a new supplement.

CBD and hemp extracts: Emerging clinical studies in dogs show potential benefits for pain and neurological conditions and suggest anxiolytic effects in some contexts; evidence for anxiety is still limited and variable, so results differ between individuals.

gal-theanine and certain nutraceutical blends: Controlled trials and veterinary reports indicate gal-theanine can reduce situational stress and promote calmer behavior in some dogs when given at appropriate doses.

Valerian, passionflower and other botanicals: Human trials and animal studies point to mild anxiolytic effects via GABAergic and serotonergic pathways; clinical evidence in dogs is smaller but suggests possible short-term calming support for situational stress.

Omega-3 fatty acids: EPA and DHA support brain health and may contribute to behavioral stability over time as part of a broader nutritional plan.

Liquid delivery benefits: Oral liquids and sublingual tinctures can improve bioavailability and allow precise, weight-based dosing; however, onset times and absorption depend on formulation and whether the product is given with food.

Quality and safety notes: Look for third-party lab testing for cannabinoid content and contaminants, clear dosing charts, and veterinary guidance; consult your vet before combining supplements with prescription medications.

In United States, subscription liquid supplements are a practical choice for owners who need adjustable dosing, palatable flavors, and regular deliveries for multiple dogs. The five products featured here—Honest Paws Calm CBD Oil, Pet Releaf Hemp Oil 330, Bailey's CBD Pet Tincture, NaturPet Stress & Anxiety, and Omega Alpha E-Z Rest—represent different strengths: Honest Paws Calm CBD Oil stands out for flexible dosing, subscription controls, and transparent testing, making it our recommended starting option for owners seeking a balance of convenience and lab-backed quality. Pet Releaf Hemp Oil 330 and Bailey's CBD Pet Tincture suit owners focused on hemp-based approaches where permitted. NaturPet Stress & Anxiety and Omega Alpha E-Z Rest provide herbal and nutraceutical blends for non-CBD users or adjunctive support. We hope you found what you were looking for; refine or expand your search using the site search if you want filters by ingredient, potency, or subscription terms, and consult your veterinarian to tailor choices to your dog's health and local regulations.

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