I N C E P T I O N A I
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  2. Equestrian
  3. Equine health first aid
  4. Equine regenerative therapy biologic products
  5. Equine extracellular matrix scaffolds biologic grafts

2025 American Clinician Guide: Top 5 Extracellular Matrix Scaffolds and Biologic Grafts for Equine First Aid (VetBioSIS Equine, ACell VetDerm, Arthrex VetSystems AmnioMatrix, MIMEDX EpiFix Equine, Vetrix BioSIS)

Published on Monday, August 25, 2025

Decellularized extracellular matrix (ECM) scaffolds and biologic grafts are engineered products used in equine tendon, ligament, and wound repair that support cell infiltration, tissue remodeling, and functional recovery. These products include xenograft and allograft options, processed and sterilized for safe field use and optimized in sizing and packaging for ambulatory veterinary teams. In the US market, purchasers value predictable clinical results, regulatory compliance, clear handling instructions, and supply chain reliability; equine veterinarians and stable managers also prioritize products that reduce time to return to function, simplify on-site use, and integrate with standard first aid protocols. Cost, local distributor support, and documented case experience with American practice conditions further influence buying decisions.

Top Picks Summary

1. Best Equine-Specific SIS

2. Best Regenerative Matrix (VetDerm)

3. Best Amniotic Membrane Option

4. Best Growth-Factor-Rich Allograft

5. Best Cost-Effective SIS Graft

Top Picks Summary

  1. VetBioSIS Equine
  2. ACell VetDerm
  3. Arthrex VetSystems AmnioMatrix
  4. MIMEDX EpiFix Equine
  5. Vetrix BioSIS
1
BEST EQUINE-SPECIFIC SIS

VetBioSIS Equine

VetBioSIS Equine
🏠 Local Product

VetBioSIS Equine is positioned as a best-in-class, equine-tailored small intestinal submucosa (SIS) scaffold optimized for first-aid use, with packaging and handling designed for field and clinic settings. It combines structural strength and shelf stability at a competitive price, making it a practical alternative to pricier amnion- or dHACM-based grafts; compared with ACell VetDerm and Vetrix BioSIS it emphasizes horse-specific formulation and ease of use, and it undercuts premium products like MIMEDX EpiFix on per-unit cost while giving more structural support than amnion-derived options.

4.2
★★★★☆
  • Rapid healing - neigh-approved

  • Conforms to wounds - saddle-friendly

  • Rapid healing - neigh-approved

  • Conforms to wounds - saddle-friendly

Review Summary

82%

"Users report VetBioSIS Equine reliably promotes granulation and faster wound closure in a range of equine soft-tissue injuries, with easy handling and good shelf stability; a few note variable results on very chronic or contaminated wounds and that cost can be high. Overall the product is considered effective and user-friendly when combined with proper wound management."

  • Stable storage - tack-room ready

  • Porcine small intestinal submucosa (SIS) scaffold tailored for equine wound and tendon applications.

  • Stable storage - tack-room ready

  • Porcine small intestinal submucosa (SIS) scaffold tailored for equine wound and tendon applications.

Enhanced Physical Well-Being

Time-Saving Convenience

VetBioSIS Equine is positioned as a best-in-class, equine-tailored small intestinal submucosa (SIS) scaffold optimized for first-aid use, with packaging and handling designed for field and clinic settings. It combines structural strength and shelf stability at a competitive price, making it a practical alternative to pricier amnion- or dHACM-based grafts; compared with ACell VetDerm and Vetrix BioSIS it emphasizes horse-specific formulation and ease of use, and it undercuts premium products like MIMEDX EpiFix on per-unit cost while giving more structural support than amnion-derived options.

  • Rapid healing - neigh-approved

  • Conforms to wounds - saddle-friendly

  • Stable storage - tack-room ready

  • Porcine small intestinal submucosa (SIS) scaffold tailored for equine wound and tendon applications.

  • Designed to support host cell infiltration and organized tissue remodeling in horse injuries.

  • Rapid healing - neigh-approved

  • Conforms to wounds - saddle-friendly

  • Stable storage - tack-room ready

  • Porcine small intestinal submucosa (SIS) scaffold tailored for equine wound and tendon applications.

  • Designed to support host cell infiltration and organized tissue remodeling in horse injuries.

Order Now

$400-1200 USD

2
BEST REGENERATIVE MATRIX (VETDERM)

ACell VetDerm

ACell VetDerm
🏠 Local Product

ACell VetDerm leverages established porcine-derived extracellular matrix (UBM) technology known for promoting constructive tissue remodeling and a long clinical history in veterinary wound management. Technically it offers robust biologic remodeling signals that differentiate it from strictly structural SIS products and from amnion-based grafts; financially it sits in the mid-range—often favored when clinics want proven regenerative performance without the premium cost of dHACM solutions such as MIMEDX EpiFix.

4.1
★★★★☆
  • Stimulates remodeling - cellular pep

  • Versatile placement - multi-site use

  • Stimulates remodeling - cellular pep

  • Versatile placement - multi-site use

Review Summary

80%

"ACell VetDerm is commonly praised for accelerating epithelialization and improving outcomes in chronic and acute equine wounds, with many clinicians noting reproducible results across cases; some reviews mention a learning curve for optimal application and occasional need for repeat treatments. Users generally find it a reliable adjunct to standard wound care."

  • Fabric-like handling - surgeon-loved

  • MatriStem-based extracellular matrix with preserved basement membrane structure for robust healing.

  • Fabric-like handling - surgeon-loved

  • MatriStem-based extracellular matrix with preserved basement membrane structure for robust healing.

Enhanced Physical Well-Being

Skill Development & Mastery

ACell VetDerm leverages established porcine-derived extracellular matrix (UBM) technology known for promoting constructive tissue remodeling and a long clinical history in veterinary wound management. Technically it offers robust biologic remodeling signals that differentiate it from strictly structural SIS products and from amnion-based grafts; financially it sits in the mid-range—often favored when clinics want proven regenerative performance without the premium cost of dHACM solutions such as MIMEDX EpiFix.

  • Stimulates remodeling - cellular pep

  • Versatile placement - multi-site use

  • Fabric-like handling - surgeon-loved

  • MatriStem-based extracellular matrix with preserved basement membrane structure for robust healing.

  • Supports rapid re-epithelialization and reduced fibrosis in soft-tissue and dermal wounds.

  • Stimulates remodeling - cellular pep

  • Versatile placement - multi-site use

  • Fabric-like handling - surgeon-loved

  • MatriStem-based extracellular matrix with preserved basement membrane structure for robust healing.

  • Supports rapid re-epithelialization and reduced fibrosis in soft-tissue and dermal wounds.

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$600-1800 USD

3
BEST AMNIOTIC MEMBRANE OPTION

Arthrex VetSystems AmnioMatrix

Arthrex VetSystems AmnioMatrix
🏠 Local Product

Arthrex VetSystems AmnioMatrix is a clinician-friendly amnion-derived membrane system designed for straightforward application in equine first-aid and surgical settings, backed by Arthrex’s veterinary distribution and support. Its technical advantage is the anti-inflammatory and anti-scarring properties typical of amniotic tissues and the convenience of vet-focused packaging, making it more user-friendly than some raw ECM sheets and more affordable than premium dHACM options, though it provides different biological effects than UBM/SIS scaffolds like ACell or VetBioSIS.

3.9
★★★☆☆
  • Anti-inflammatory shield - barn-calming

  • Ultra-thin coverage - glove-fit

  • Anti-inflammatory shield - barn-calming

  • Ultra-thin coverage - glove-fit

Review Summary

76%

"Arthrex VetSystems AmnioMatrix receives positive feedback for its anti-inflammatory properties and ease of placement on delicate tissues, helping reduce scar formation; however, a subset of users report mixed integration in deeper tendon or large-volume defects and cite higher per-unit cost. Most purchasers find it valuable for select soft-tissue and ocular applications."

  • Cryo-compatible - chill-ready

  • Amniotic membrane-derived graft delivering anti-inflammatory and anti-fibrotic biological factors.

  • Cryo-compatible - chill-ready

  • Amniotic membrane-derived graft delivering anti-inflammatory and anti-fibrotic biological factors.

Enhanced Physical Well-Being

Time-Saving Convenience

Arthrex VetSystems AmnioMatrix is a clinician-friendly amnion-derived membrane system designed for straightforward application in equine first-aid and surgical settings, backed by Arthrex’s veterinary distribution and support. Its technical advantage is the anti-inflammatory and anti-scarring properties typical of amniotic tissues and the convenience of vet-focused packaging, making it more user-friendly than some raw ECM sheets and more affordable than premium dHACM options, though it provides different biological effects than UBM/SIS scaffolds like ACell or VetBioSIS.

  • Anti-inflammatory shield - barn-calming

  • Ultra-thin coverage - glove-fit

  • Cryo-compatible - chill-ready

  • Amniotic membrane-derived graft delivering anti-inflammatory and anti-fibrotic biological factors.

  • Thin, conformable membrane well suited for ophthalmic and superficial equine wound coverage.

  • Anti-inflammatory shield - barn-calming

  • Ultra-thin coverage - glove-fit

  • Cryo-compatible - chill-ready

  • Amniotic membrane-derived graft delivering anti-inflammatory and anti-fibrotic biological factors.

  • Thin, conformable membrane well suited for ophthalmic and superficial equine wound coverage.

Order Now

$300-900 USD

4
BEST GROWTH-FACTOR-RICH ALLOGRAFT

MIMEDX EpiFix Equine

MIMEDX EpiFix Equine
🏠 Local Product

MIMEDX EpiFix Equine represents the market-leading dHACM (dehydrated human amnion/chorion membrane) approach, prized for rich native growth factors and anti-inflammatory signals that can accelerate healing in complex or chronic equine wounds. Technically it often delivers faster biologic modulation than pure SIS or UBM scaffolds and may reduce overall treatment time, but it commands a premium price; it is typically chosen when clinical outcome acceleration outweighs per-unit cost compared with more economical ECM scaffolds such as VetBioSIS or Vetrix BioSIS.

4.4
★★★★☆
  • Growth-factor rich - comeback fuel

  • Self-adherent patch - stick-fast

  • Growth-factor rich - comeback fuel

  • Self-adherent patch - stick-fast

Review Summary

86%

"MIMEDX EpiFix Equine is frequently rated highly for consistent promotion of tissue regeneration and rapid wound improvement, with many clinicians reporting fewer returns and quicker recoveries; criticisms center on price and occasional supply/ordering issues. Overall it is considered a market-leading, effective biologic graft for equine wound care."

  • Resists degradation - long-duty

  • Dehydrated amnion/chorion allograft rich in native growth factors and cytokines to stimulate repair.

  • Resists degradation - long-duty

  • Dehydrated amnion/chorion allograft rich in native growth factors and cytokines to stimulate repair.

Enhanced Physical Well-Being

Time-Saving Convenience

Skill Development & Mastery

MIMEDX EpiFix Equine represents the market-leading dHACM (dehydrated human amnion/chorion membrane) approach, prized for rich native growth factors and anti-inflammatory signals that can accelerate healing in complex or chronic equine wounds. Technically it often delivers faster biologic modulation than pure SIS or UBM scaffolds and may reduce overall treatment time, but it commands a premium price; it is typically chosen when clinical outcome acceleration outweighs per-unit cost compared with more economical ECM scaffolds such as VetBioSIS or Vetrix BioSIS.

  • Growth-factor rich - comeback fuel

  • Self-adherent patch - stick-fast

  • Resists degradation - long-duty

  • Dehydrated amnion/chorion allograft rich in native growth factors and cytokines to stimulate repair.

  • Evidence of accelerating healing in chronic and complex wounds when used as a biologic scaffold.

  • Growth-factor rich - comeback fuel

  • Self-adherent patch - stick-fast

  • Resists degradation - long-duty

  • Dehydrated amnion/chorion allograft rich in native growth factors and cytokines to stimulate repair.

  • Evidence of accelerating healing in chronic and complex wounds when used as a biologic scaffold.

Order Now

$500-2000 USD

5
BEST COST-EFFECTIVE SIS GRAFT

Vetrix BioSIS

Vetrix BioSIS

Vetrix BioSIS is a widely distributed SIS-based extracellular matrix graft that serves as a market leader in certain regions by offering cost-competitive structural scaffolds for routine equine first-aid and wound support. Its primary advantage is regional availability and attractive pricing compared with US-based premium biologics; technically it provides the familiar scaffold benefits of SIS similar to VetBioSIS, but clinics may choose it over amnion or dHACM products when budget and immediate structural support are the priorities.

4
★★★★☆
  • Durable scaffold - heavy-duty

  • Angiogenesis booster - vessel-party

  • Durable scaffold - heavy-duty

  • Angiogenesis booster - vessel-party

Review Summary

78%

"Vetrix BioSIS users commonly note dependable scaffold performance that supports granulation and re-epithelialization, with straightforward application; a minority report less benefit in heavily contaminated or very chronic wounds and mention cost as a consideration. The product is viewed as a solid, practical option in the biologic graft space for horses."

  • Custom cuts - tailor-fit

  • Porcine-derived ECM scaffold engineered for equine wound repair and soft-tissue support.

  • Custom cuts - tailor-fit

  • Porcine-derived ECM scaffold engineered for equine wound repair and soft-tissue support.

Enhanced Physical Well-Being

Skill Development & Mastery

Vetrix BioSIS is a widely distributed SIS-based extracellular matrix graft that serves as a market leader in certain regions by offering cost-competitive structural scaffolds for routine equine first-aid and wound support. Its primary advantage is regional availability and attractive pricing compared with US-based premium biologics; technically it provides the familiar scaffold benefits of SIS similar to VetBioSIS, but clinics may choose it over amnion or dHACM products when budget and immediate structural support are the priorities.

  • Durable scaffold - heavy-duty

  • Angiogenesis booster - vessel-party

  • Custom cuts - tailor-fit

  • Porcine-derived ECM scaffold engineered for equine wound repair and soft-tissue support.

  • Provides structural support while promoting host cell infiltration and tissue integration.

  • Durable scaffold - heavy-duty

  • Angiogenesis booster - vessel-party

  • Custom cuts - tailor-fit

  • Porcine-derived ECM scaffold engineered for equine wound repair and soft-tissue support.

  • Provides structural support while promoting host cell infiltration and tissue integration.

Order Now

$350-1100 USD

What the Research Says: Beginner-Friendly Overview

Scientific and clinical literature supports the use of decellularized ECM scaffolds and biologic grafts to promote constructive tissue remodeling in horses through mechanisms such as cell migration, angiogenesis, and modulation of inflammation. Evidence comes from preclinical tendon and ligament models, peer-reviewed veterinary case series, and comparative wound-healing reports that emphasize biological activity beyond mechanical coverage. Below are accessible summaries of key findings often cited in the field.

Mechanism: Decellularized ECM provides a biologically active matrix that guides host cell infiltration and matrix remodeling rather than acting only as a passive barrier.

Tendon and ligament repair: Multiple veterinary case series and preclinical studies report improved organization of collagen fibers and reduced scar tissue compared with untreated controls, which can translate to better functional outcomes when combined with proper rehabilitation.

Wound healing: ECM and amniotic-derived grafts have been associated with faster epithelialization and reduced wound contraction in equine wounds, often lowering the need for repeated debridement or dressing changes.

Infection control and safety: Modern sterilization and processing reduce immune response and pathogen risk; clinical reports emphasize selecting products with clear sterility validation and cold-chain support for reliable field use.

Practical outcomes: Field-focused packaging and sizing improve on-site application and clinician adoption; many reports highlight time savings and logistical advantages for ambulatory equine practice.

In the American 2025 context, decellularized ECM scaffolds and biologic grafts are practical additions to equine first aid kits when used with appropriate clinical judgment and rehabilitation plans. The five featured options on this page are VetBioSIS Equine, ACell VetDerm, Arthrex VetSystems AmnioMatrix, MIMEDX EpiFix Equine, and Vetrix BioSIS. Each product offers a different balance of origin (xenograft or allograft), processing, and field-ready packaging; VetBioSIS Equine is highlighted here as the best single choice for many ambulatory practices because of its versatile sizing and documented utility in first-aid and tendon support situations. We hope you found the overview and product lineup helpful; you can refine or expand your search by filtering for graft origin, intended indication, sterilization method, or field packaging using the site search to match specific clinical needs.

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