I N C E P T I O N A I

Top 6 Digestive and Probiotic Supplements for Horses in the United States (2025): Veterinarian-Recommended Options to Stabilize Hindgut, Reduce Gas and Support Ulcer and Recovery Care

Prebiotics, probiotics, digestive enzymes and gastric support formulas designed to stabilize hindgut flora, reduce gas and support ulcer-prone horses make up a fast-growing category for American horse owners in 2025. These products appeal because they target common, performance-limiting issues such as colic risk from hindgut imbalance, gas and bloating, reduced feed efficiency during transitions, and gastric ulcers tied to stress or training. Consumers in the United States are increasingly looking for science-backed formulations, veterinarian endorsements, clear dosing for different sizes and situations, and options available through local retailers and online suppliers. The category includes specialized formulas for transitional feeding, recovery after antibiotic treatment, daily maintenance for performance and broodmares, and targeted gastric buffers and alginate-based supports for ulcer-prone horses. Practical benefits that drive purchases include faster recovery, steadier temperament, improved feed utilization, and the confidence of products that are formulated or verified by equine professionals.

Top Picks Summary

  1. Mad Barn Optimum Probiotic Paste
  2. Omega Alpha Probiotic 8 Plus
  3. Purina SuperSport Gastro Health
  4. Omega Alpha GastraFX
  5. Mad Barn Visceral+ Gastric Support
  6. Vetoquinol Zylkene Equine
1
BEST PROBIOTIC PASTES FOR HORSES

Mad Barn Optimum Probiotic Paste

Mad Barn

Mad Barn Optimum Probiotic Paste differentiates itself through transparency and precision: multi-strain, high-count formulas with clearly listed strains and CFU targets aimed at performance and metabolic support. Compared with legacy brands it appeals to evidence-oriented owners and stables, and its direct-to-consumer and subscription pricing models can deliver better long-term value for ongoing supplementation despite a similar per-dose cost to other premium pastes.

4.2
Show More Probiotic Pastes for Horses
  • Multi-strain boost

  • Daily gut balance

  • Multi-strain boost

  • Daily gut balance

Review Summary

82%

"Owners praise Mad Barn Optimum Probiotic Paste for improving manure consistency and overall gut balance, noting good palatability and clear short-term benefits; a few report less effect in chronic or severe issues."

  • Trailer-ready tummy

  • Multi-strain probiotic and prebiotic blend formulated to support hindgut microbial balance.

  • Trailer-ready tummy

  • Multi-strain probiotic and prebiotic blend formulated to support hindgut microbial balance.

Increased Safety & Security

Time-Saving Convenience

Mad Barn Optimum Probiotic Paste differentiates itself through transparency and precision: multi-strain, high-count formulas with clearly listed strains and CFU targets aimed at performance and metabolic support. Compared with legacy brands it appeals to evidence-oriented owners and stables, and its direct-to-consumer and subscription pricing models can deliver better long-term value for ongoing supplementation despite a similar per-dose cost to other premium pastes.

Order Now

$55-85 USD

2
BEST PROBIOTIC POWDERS FOR HORSES

Omega Alpha Probiotic 8 Plus

Omega Alpha

Omega Alpha Probiotic 8 Plus is a premium Australian powder that emphasizes strain diversity and added digestive support, marketed toward owners seeking a comprehensive, export-quality probiotic formula for performance and leisure horses. It typically commands a higher price-per-dose than mainstream options but delivers technical advantages in ingredient sourcing and multi-component formulation that rival Mad Barn’s research focus while offering a different geographic supply chain and product positioning.

4
Show More Probiotic Powders for Horses
  • Eight strains

  • Immune support

  • Eight strains

  • Immune support

Review Summary

78%

"Omega Alpha Probiotic 8 Plus gets positive marks for including multiple strains and improving overall gut balance, though a minority find responses variable between individual horses. Generally viewed as a solid multi-strain option at a mid-range price point."

  • Multi-strain zest

  • Includes multiple probiotic strains to support diverse gut flora.

  • Multi-strain zest

  • Includes multiple probiotic strains to support diverse gut flora.

Increased Safety & Security

Time-Saving Convenience

Omega Alpha Probiotic 8 Plus is a premium Australian powder that emphasizes strain diversity and added digestive support, marketed toward owners seeking a comprehensive, export-quality probiotic formula for performance and leisure horses. It typically commands a higher price-per-dose than mainstream options but delivers technical advantages in ingredient sourcing and multi-component formulation that rival Mad Barn’s research focus while offering a different geographic supply chain and product positioning.

Order Now

$60-110 USD

3
BEST PREBIOTIC PELLETS FOR HORSES

Purina SuperSport Gastro Health

Purina SuperSport Gastro Health
🏠 Local Product

Purina SuperSport Gastro Health holds a market-leader position thanks to wide availability, large-scale manufacturing controls and consistent quality that make it easy to source for barns and competitions. While not as niche or concentrated as Mad Barn or Tribute, Purina’s economies of scale often translate into competitive retail pricing and dependable supply, which is a financial advantage for programs that need consistent, large-quantity provisioning.

4.1
Show More Prebiotic Pellets for Horses
  • Performance gut care — pro-tested

  • Palatable mint twist — picky eaters

  • Performance gut care — pro-tested

  • Palatable mint twist — picky eaters

Review Summary

82%

"Performance horse owners commonly report reduced gastric upset and faster post-exertion recovery with good feed acceptance; a minority say it was less effective for severe, long-standing ulcers."

  • Stable-ready scoop — quick feed

  • Designed to support gastric and hindgut health in athletic and competition horses.

  • Stable-ready scoop — quick feed

  • Designed to support gastric and hindgut health in athletic and competition horses.

Increased Safety & Security

Time-Saving Convenience

Purina SuperSport Gastro Health holds a market-leader position thanks to wide availability, large-scale manufacturing controls and consistent quality that make it easy to source for barns and competitions. While not as niche or concentrated as Mad Barn or Tribute, Purina’s economies of scale often translate into competitive retail pricing and dependable supply, which is a financial advantage for programs that need consistent, large-quantity provisioning.

Order Now

$70-140 USD

4
BEST DIGESTIVE ENZYME SUPPLEMENTS FOR HORSES

Omega Alpha GastraFX

Omega Apha
🏠 Local Product

Omega Alpha GastraFX is positioned as a market leader for horses needing intensive gastric and digestive enzyme support, pairing clinically-oriented enzyme blends with mucosal-support ingredients to address ulcers and gas proactively. Its technical advantage is a focused, therapeutic-grade ingredient set that typically commands a premium price but can reduce secondary veterinary costs compared with generic probiotics or herbal-only products.

4.2
Show More Digestive Enzyme Supplements for Horses
  • Gastric-soothing relief

  • Quick-mix convenience

  • Gastric-soothing relief

  • Quick-mix convenience

Review Summary

82%

"Horse owners frequently note reduced signs of gastric discomfort and fewer digestive upsets with continued use; effective for many, but some report slower results and a higher price compared with generics."

  • Herbal burp charm

  • Targeted toward gastric comfort with supportive enzymes and gut-conditioning ingredients to help manage gastric irritation and acidity.

  • Herbal burp charm

  • Targeted toward gastric comfort with supportive enzymes and gut-conditioning ingredients to help manage gastric irritation and acidity.

Increased Safety & Security

Recreational Enjoyment

Time-Saving Convenience

Omega Alpha GastraFX is positioned as a market leader for horses needing intensive gastric and digestive enzyme support, pairing clinically-oriented enzyme blends with mucosal-support ingredients to address ulcers and gas proactively. Its technical advantage is a focused, therapeutic-grade ingredient set that typically commands a premium price but can reduce secondary veterinary costs compared with generic probiotics or herbal-only products.

Order Now

$70-110 USD

5
BEST GASTRIC ULCER SUPPORT FOR HORSES

Mad Barn Visceral+ Gastric Support

Mad Barn Visceral+ Gastric Support

Mad Barn Visceral+ stands out as a market leader for its research-driven, multi-ingredient approach aimed at both gastric and microbiome health, backed by personalized feeding guidance and lab-based diagnostics. Though typically positioned at a higher price point than commodity supplements like Purina Outlast, its technical advantage is a targeted, science-focused formulation and individualized recommendations that can outperform one-size-fits-all options for horses with complex digestive profiles.

4.6
Show More Gastric Ulcer Support for Horses
  • Mucosal care — probiotic zing

  • Absorption boost — lab-smarts

  • Mucosal care — probiotic zing

  • Absorption boost — lab-smarts

Review Summary

90%

"Customers frequently report noticeable improvement in gastric comfort and appetite and appreciate the ingredient transparency; a few cite the price and occasional variable response between horses."

  • Feed-safe blend — unflavored wink

  • Concentrated formula aimed at supporting gastric mucosal health and overall digestive tract balance.

  • Feed-safe blend — unflavored wink

  • Concentrated formula aimed at supporting gastric mucosal health and overall digestive tract balance.

Increased Safety & Security

Time-Saving Convenience

Mad Barn Visceral+ stands out as a market leader for its research-driven, multi-ingredient approach aimed at both gastric and microbiome health, backed by personalized feeding guidance and lab-based diagnostics. Though typically positioned at a higher price point than commodity supplements like Purina Outlast, its technical advantage is a targeted, science-focused formulation and individualized recommendations that can outperform one-size-fits-all options for horses with complex digestive profiles.

Order Now

$80-140 USD

6

Vetoquinol Zylkene Equine delivers a natural, non-sedating calming ingredient (alpha-casozepine) to reduce stress-related gastric upset during transport, training transitions or antibiotic recovery. It is recognized here for addressing the behavioral and stress component of digestive disturbance rather than directly repopulating gut flora, making it a technically complementary option to probiotic and buffering products on this list and often a cost-effective adjunct for horses whose issues are stress-driven. Used alongside microbiome-focused supplements, Zylkene helps minimize the stress triggers that can impede recovery.

3.9
Show More Transition and Antibiotic Recovery Digestive Support for Horses
  • Natural calming aid

  • Stress-reduction support

  • Natural calming aid

  • Stress-reduction support

Review Summary

74%

"Owners report modest but reliable calming effects during stressful events, with mixed results on long-term behavior; palatability and individual response vary. It's often recommended by vets for short-term stress management."

  • Calm-inducing — zen vibes

  • Contains a natural casein-derived peptide (alpha-casozepine) to reduce stress-related behaviours that can exacerbate digestive upset.

  • Calm-inducing — zen vibes

  • Contains a natural casein-derived peptide (alpha-casozepine) to reduce stress-related behaviours that can exacerbate digestive upset.

Increased Safety & Security

Time-Saving Convenience

Vetoquinol Zylkene Equine delivers a natural, non-sedating calming ingredient (alpha-casozepine) to reduce stress-related gastric upset during transport, training transitions or antibiotic recovery. It is recognized here for addressing the behavioral and stress component of digestive disturbance rather than directly repopulating gut flora, making it a technically complementary option to probiotic and buffering products on this list and often a cost-effective adjunct for horses whose issues are stress-driven. Used alongside microbiome-focused supplements, Zylkene helps minimize the stress triggers that can impede recovery.

Order Now

$40-80 USD

What the Research Says About Equine Digestive Support

A growing body of veterinary research supports targeted use of prebiotics, probiotics, digestive enzymes and gastric support in horses. Studies and clinical reports indicate these interventions can help re-establish a healthy hindgut microbiota after dietary changes or antibiotics, improve fiber and starch digestion in some cases, and reduce clinical signs associated with digestive upset. Gastric support products that buffer stomach acid or form protective layers can reduce ulcer severity when used as part of a management plan. Importantly, outcomes depend on product selection, correct dosing, and combining supplements with good feeding and management practices recommended by a veterinarian.

Probiotics: Clinical trials and field studies show select live microbial strains can help restore normal hindgut populations after antibiotic use and reduce episodes of loose feces during dietary transitions.

Prebiotics: Non-digestible fibers such as inulin or fructooligosaccharides feed beneficial microbes and support more stable fermentation patterns in the hindgut.

Digestive enzymes: Supplemental enzymes can aid starch and fiber breakdown in horses with compromised digestion or during high-concentrate feeding, improving feed efficiency.

Gastric support: Buffering agents, alginate-based protectants and pH modulators have been shown to reduce ulcer scores in controlled studies when used with dietary and management changes.

Timing and combination matter: Research highlights better outcomes when probiotics and prebiotics are started early in a transition or concurrently with antibiotic therapy rather than waiting until symptoms escalate.

Safety and regulation: Studies emphasize strain-specific effects and the need for quality manufacturing; working with a veterinarian helps match products to the horse's clinical needs and avoid unnecessary overlap or interactions.

Whether you are managing a performance horse, bringing a pasture boarder through a feed change, or helping a horse recover from antibiotics, the top 6 digestive and probiotic supplements for horses in the United States for 2025 cover the main needs: hindgut stability, gas reduction, ulcer support and transition care. We hope this guide helped you identify the right direction. Use the search or filters to refine by purpose, veterinarian recommendations, ingredient type, or price to find the exact product that suits your horse and region in the USA.