Douxo S3 PYO Antiseptic Antifungal Shampoo
Douxo S3 PYO is positioned as a prescription-strength, barrier-supporting antiseptic and antifungal shampoo that combines broad antimicrobial actives with skin-restoring ingredients to reduce recurrence. It stands out against simpler antiseptic washes by pairing clinical-level pathogen control with phytosphingosine-based skin barrier support, making it a go-to premium choice for veterinarians despite a higher price point. Compared with other products on this list, Douxo emphasizes both antimicrobial efficacy and long-term skin health, which can reduce repeat treatments and associated costs over time.
Pyo-targeted foam
Relief for itch
Pyo-targeted foam
Relief for itch
Review Summary
"Users generally report Douxo S3 PYO works very well for bacterial and fungal skin issues, leaving skin calmer and less odorous; common negatives are higher cost and some users wanting more lather. Overall many owners find it gentle and effective with repeated use."
Veterinary favorite
Contains octenidine and Ophytrium to reduce yeast and bacterial load while supporting skin barrier
Veterinary favorite
Contains octenidine and Ophytrium to reduce yeast and bacterial load while supporting skin barrier
Increased Safety & Security
Time-Saving Convenience
Douxo S3 PYO is positioned as a prescription-strength, barrier-supporting antiseptic and antifungal shampoo that combines broad antimicrobial actives with skin-restoring ingredients to reduce recurrence. It stands out against simpler antiseptic washes by pairing clinical-level pathogen control with phytosphingosine-based skin barrier support, making it a go-to premium choice for veterinarians despite a higher price point. Compared with other products on this list, Douxo emphasizes both antimicrobial efficacy and long-term skin health, which can reduce repeat treatments and associated costs over time.
Pyo-targeted foam
Relief for itch
Veterinary favorite
Contains octenidine and Ophytrium to reduce yeast and bacterial load while supporting skin barrier
Gentle surfactants and conditioning agents allow more frequent therapeutic baths without excessive drying
Pyo-targeted foam
Relief for itch
Veterinary favorite
Contains octenidine and Ophytrium to reduce yeast and bacterial load while supporting skin barrier
Gentle surfactants and conditioning agents allow more frequent therapeutic baths without excessive drying
$25-40 USD
Malaseb Medicated Shampoo
Malaseb is a long-established medicated shampoo combining chlorhexidine and an imidazole antifungal, favored for reliably tackling both bacterial and yeast infections at a cost-effective price point. Its straightforward, potent antiseptic/antifungal formulation makes it a practical clinic staple for heavy-duty cleansing when compared with barrier-focused or OTC spray options. For practices seeking an economical, proven option for short-course washes, Malaseb often delivers clinical results with predictable dosing and inventory simplicity.
Anti-yeast punch
Deep skin cleanse
Anti-yeast punch
Deep skin cleanse
Review Summary
"Malaseb is widely praised for reliably clearing yeast and bacterial infections and providing good value, though some find it drying or strong-smelling and require follow-up treatments. Most reviewers say it produces noticeable improvement when used as directed."
Clinic-grade strength
Contains chlorhexidine and miconazole to target both bacterial and fungal infections commonly causing seborrhea
Clinic-grade strength
Contains chlorhexidine and miconazole to target both bacterial and fungal infections commonly causing seborrhea
Increased Safety & Security
Time-Saving Convenience
Malaseb is a long-established medicated shampoo combining chlorhexidine and an imidazole antifungal, favored for reliably tackling both bacterial and yeast infections at a cost-effective price point. Its straightforward, potent antiseptic/antifungal formulation makes it a practical clinic staple for heavy-duty cleansing when compared with barrier-focused or OTC spray options. For practices seeking an economical, proven option for short-course washes, Malaseb often delivers clinical results with predictable dosing and inventory simplicity.
Anti-yeast punch
Deep skin cleanse
Clinic-grade strength
Contains chlorhexidine and miconazole to target both bacterial and fungal infections commonly causing seborrhea
Therapeutic shampoo that helps remove scales, reduce greasiness, and control odor
Anti-yeast punch
Deep skin cleanse
Clinic-grade strength
Contains chlorhexidine and miconazole to target both bacterial and fungal infections commonly causing seborrhea
Therapeutic shampoo that helps remove scales, reduce greasiness, and control odor
$20-35 USD
Veterinary Formula Clinical Care Antiseptic & Antifungal Spray
Veterinary Formula Clinical Care offers a consumer-oriented antiseptic and antifungal spray that prioritizes ease of use, spot treatment and affordability for pet owners. While it generally has lower active concentrations than prescription shampoos, its spray format and retail availability make it a convenient first-line or adjunct option for minor localized lesions and home care. Compared with prescription shampoos like Douxo or Malaseb, this product trades some potency for accessibility and lower upfront cost, which can improve adherence and reduce clinic visits for mild cases.
Quick spot spray
No-rinse action
Quick spot spray
No-rinse action
Review Summary
"Veterinary Formula Clinical Care Antiseptic & Antifungal Spray is appreciated for convenient spot-treatment and quick application, but some users find it less potent than medicated shampoos and a few report mild irritation. It’s commonly used for minor infections and hotspots with generally favorable outcomes."
Portable pocket hero
Ready-to-use antiseptic and antifungal spray for spot treatment of localized skin lesions and hotspots
Portable pocket hero
Ready-to-use antiseptic and antifungal spray for spot treatment of localized skin lesions and hotspots
Increased Safety & Security
Time-Saving Convenience
Veterinary Formula Clinical Care offers a consumer-oriented antiseptic and antifungal spray that prioritizes ease of use, spot treatment and affordability for pet owners. While it generally has lower active concentrations than prescription shampoos, its spray format and retail availability make it a convenient first-line or adjunct option for minor localized lesions and home care. Compared with prescription shampoos like Douxo or Malaseb, this product trades some potency for accessibility and lower upfront cost, which can improve adherence and reduce clinic visits for mild cases.
Quick spot spray
No-rinse action
Portable pocket hero
Ready-to-use antiseptic and antifungal spray for spot treatment of localized skin lesions and hotspots
Spray format enables targeted application to wounds, folds, and difficult-to-reach areas
Quick spot spray
No-rinse action
Portable pocket hero
Ready-to-use antiseptic and antifungal spray for spot treatment of localized skin lesions and hotspots
Spray format enables targeted application to wounds, folds, and difficult-to-reach areas
$18-28 USD
Zymox Topical Spray with Hydrocortisone
Zymox Topical Spray leverages a proprietary enzyme-based antimicrobial system combined with hydrocortisone to deliver both antimicrobial activity and fast anti-inflammatory relief without relying solely on traditional antibiotics. This dual-action, non-antibiotic approach makes Zymox attractive for cases where inflammation control is a priority and when minimizing antibiotic exposure is desirable, positioning it as a clinically differentiated—if premium-priced—option. Compared to standard chlorhexidine/miconazole treatments, Zymox’s enzymatic technology and steroid adjunct often provide quicker symptomatic relief, which can reduce ancillary medication costs and improve patient comfort.
Enzyme therapy spray
Itch-calming cortisone
Enzyme therapy spray
Itch-calming cortisone
Review Summary
"Zymox Topical Spray with Hydrocortisone is frequently reported to reduce itching and inflammation and help manage infections without antibiotics; reviewers like its ease of use but note it’s relatively expensive and results vary by case. Many owners see faster symptom relief compared with standard topical products."
Leaves fur fluffy
LP3 enzyme system helps reduce microbes without relying on traditional antibiotics or steroids alone
Leaves fur fluffy
LP3 enzyme system helps reduce microbes without relying on traditional antibiotics or steroids alone
Increased Safety & Security
Time-Saving Convenience
Zymox Topical Spray leverages a proprietary enzyme-based antimicrobial system combined with hydrocortisone to deliver both antimicrobial activity and fast anti-inflammatory relief without relying solely on traditional antibiotics. This dual-action, non-antibiotic approach makes Zymox attractive for cases where inflammation control is a priority and when minimizing antibiotic exposure is desirable, positioning it as a clinically differentiated—if premium-priced—option. Compared to standard chlorhexidine/miconazole treatments, Zymox’s enzymatic technology and steroid adjunct often provide quicker symptomatic relief, which can reduce ancillary medication costs and improve patient comfort.
Enzyme therapy spray
Itch-calming cortisone
Leaves fur fluffy
LP3 enzyme system helps reduce microbes without relying on traditional antibiotics or steroids alone
Includes low-dose hydrocortisone to rapidly relieve inflammation and itching in localized areas
Enzyme therapy spray
Itch-calming cortisone
Leaves fur fluffy
LP3 enzyme system helps reduce microbes without relying on traditional antibiotics or steroids alone
Includes low-dose hydrocortisone to rapidly relieve inflammation and itching in localized areas
$25-45 USD
Curaseb Chlorhexidine 4% Shampoo
Curaseb Chlorhexidine 4% Shampoo is a high-concentration antiseptic wash aimed at aggressive microbial control, offering a straightforward, vet-preferred option for heavy colonization and acute infections. Its relatively high chlorhexidine level provides strong biocidal activity and is often a cost-efficient choice when intense decontamination is required, though it may necessitate careful use to avoid over-drying the skin compared with gentler barrier-focused products. In comparison to enzyme-based or lower-concentration products, Curaseb provides a powerful, no-frills antiseptic solution that can shorten treatment courses and reduce overall antimicrobial product use in severe cases.
4% chlorhexidine power
Tackles tough bugs
4% chlorhexidine power
Tackles tough bugs
Review Summary
"Curaseb Chlorhexidine 4% Shampoo is commonly described as highly effective against stubborn bacterial and yeast infections, especially severe cases, though it can be drying and has a medicinal scent; some users limit frequency of use for skin sensitivity. Overall reviewers rate it highly for potency and results."
Fresh-mint finish
Contains 4% chlorhexidine for broad-spectrum antibacterial activity against common skin pathogens
Fresh-mint finish
Contains 4% chlorhexidine for broad-spectrum antibacterial activity against common skin pathogens
Increased Safety & Security
Time-Saving Convenience
Curaseb Chlorhexidine 4% Shampoo is a high-concentration antiseptic wash aimed at aggressive microbial control, offering a straightforward, vet-preferred option for heavy colonization and acute infections. Its relatively high chlorhexidine level provides strong biocidal activity and is often a cost-efficient choice when intense decontamination is required, though it may necessitate careful use to avoid over-drying the skin compared with gentler barrier-focused products. In comparison to enzyme-based or lower-concentration products, Curaseb provides a powerful, no-frills antiseptic solution that can shorten treatment courses and reduce overall antimicrobial product use in severe cases.
4% chlorhexidine power
Tackles tough bugs
Fresh-mint finish
Contains 4% chlorhexidine for broad-spectrum antibacterial activity against common skin pathogens
Effective at controlling bacterial skin infections, reducing odor, and removing excess oils and debris
4% chlorhexidine power
Tackles tough bugs
Fresh-mint finish
Contains 4% chlorhexidine for broad-spectrum antibacterial activity against common skin pathogens
Effective at controlling bacterial skin infections, reducing odor, and removing excess oils and debris
$20-35 USD