Top 8 Supplements and Probiotics for Small Animals in the USA 2025 — A Veterinarian- and Research-Informed Guide to Support Digestion, Immunity, Joints and Coat Health

Martin Little Friends Original Formula targets owners seeking natural-leaning, herb-enhanced supplementation for small mammals, presenting a palatable, treat-like delivery that encourages voluntary intake. Compared to the clinical-style options in this list it often offers a better perceived value for owners prioritizing ingredient transparency and palatability, though buyers should weigh whether the dosing level matches therapeutic needs in sick or deficient animals.

Zesty Paws Mobility Bites stand out for palatability and owner-friendly administration, offering soft chews that make dosing easy for picky small animals and improve compliance. They are competitively priced versus other mid-range options like NaturVet and often include complementary functional ingredients for overall comfort, though they typically do not include the specialized ASU complex that differentiates Dasuquin.

Living World Green Botanicals is positioned as a market leader for plant-forward daily support, offering a botanical-rich formula that appeals to owners seeking gentle, natural extracts and easy daily dosing for small animals. Financially it often undercuts premium veterinary formulas while providing unique botanical actives not emphasized by the others, making it a cost-effective, natural-leaning alternative for routine supplementation.

Marshall Pet Products Pro-Biotic is positioned as a small-animal focused probiotic that many ferret owners prefer for its species-appropriate formulation and straightforward powdered delivery. It holds its place as a market leader for ferrets by balancing targeted strains and an affordable price point, making it more cost-effective for long-term use than premium, multi-ingredient formulas like Wysong. Compared with enzyme-focused options on this list, Marshall is prioritized when steady probiotic maintenance rather than acute enzyme support is the goal.

Oxbow Natural Science Digestive Support is a market leader for herbivorous small animals thanks to its prebiotic-rich, high-fiber formulation designed by a veterinary-led brand; it emphasizes long-term gut health and stool consistency. Financially attractive for routine use, Oxbow provides a different technical approach than Bene-Bac's live cultures or Sherwood's enzyme/probiotic tablets, making it the go-to for ongoing maintenance in rabbits and guinea pigs where fiber, not transient probiotics, is the primary treatment goal.

Nutri-Vet Multi-Vite Chewables is recognized as a dependable, low-cost multivitamin that typically includes essential antioxidants such as Vitamin E and supportive vitamin complex components suitable for routine antioxidant maintenance. Its financial advantage is consistent affordability and broad distribution, making it a practical everyday supplement compared with higher-priced specialty blends like Zesty Paws or vet-formulated products. Technically it offers straightforward nutrient coverage rather than the higher concentrations or joint-targeted delivery seen in Omega Alpha or VetriScience formulas.

Martin Mills' Little Friends Timothy Recovery Plus takes a natural, hay-based approach to appetite and calming support by offering highly palatable timothy hay and recovery blends that encourage grazing and steady gut motility. Technically less concentrated than medicinal supplements, it is financially attractive for long-term use and works well as a foundational, calming option alongside more targeted supplements from the other brands.