Top 6 Calming and Anxiety Supplements for Dogs in the United States (2025): Natural, Clinically Supported Picks Reviewed by Veterinarians

Pet Naturals of Vermont Calming Chews hold a strong position by offering a veterinarian-informed, straightforward herbal formulation aimed at steady, everyday support for anxious dogs at a mid-range price point. They trade a slightly narrower ingredient list for clarity and vet-oriented branding, making them a good compromise between the robust blends of Zesty Paws and the budget-focused NaturVet Quiet Moments.

VetriScience Composure Pro Chews earns a top position for delivering concentrated amino-acid support in a palatable, chewable format designed for acute stress events and everyday anxiety; this product emphasizes convenient administration and high owner compliance. Compared with powder or capsule competitors here, its technical advantage is a flavor-forward chew and often higher per-dose potency—making it a premium but practical choice for dogs that refuse pills or require fast-acting oral delivery.

NaturVet Quiet Moments is a long-standing, budget-oriented calming aid that uses a blend of traditional botanicals and amino acids to reduce stress, making it attractive for owners prioritizing affordability and broad availability. Compared to the newer or premium treats here, NaturVet typically undercuts competitors on price per serving, though its simpler formulation can mean slower onset or less pronounced effects for highly anxious dogs.

Zylkene is a veterinary-recommended capsule containing a milk-derived peptide (alpha-casozepine) with clinical data supporting its calming effects, which earns it a best-in-class position for dogs with situational stress. Its single, well-studied active ingredient provides a technically targeted approach compared with multi-ingredient nutraceuticals on this list, though it is typically positioned as a premium vet product and can be more costly than mass-market OTC options.

Bach Rescue Remedy Pet Liquid is the market-leading homeopathic option noted for its simplicity, low-cost per bottle and long shelf stability; it relies on flower essences to provide gentle, non-pharmacological support suited to mild stress events. Unlike the multi-ingredient powders and hemp supplements here, Rescue Remedy appeals to owners seeking a mild, widely available liquid that can be used frequently with minimal risk, making it a distinct, softer alternative to more technically active calming products.