Zylkene Capsules for Dogs
Zylkene holds a best-in-class position for targeted separation and noise phobia support because it delivers a single, milk-derived peptide (alpha-casozepine) in a drug-free, easy-to-dose capsule that many owners find predictable for daily use. Compared with pheromone-based Adaptil and multi-ingredient chews, Zylkene’s simplicity reduces interactions with other medications and often provides a cost-effective option for long-term maintenance without the regulatory or quality-variability concerns sometimes seen with hemp/CBD products.
Milk-protein magic
Separation whisper
Milk-protein magic
Separation whisper
Review Summary
"Most owners report Zylkene gently reduces separation and noise-related anxiety over several days to weeks with minimal side effects, though it can be insufficient alone for severe phobias."
Vet-favorite calm
Contains alpha-casozepine derived from milk protein to support short-term anxiety relief
Vet-favorite calm
Contains alpha-casozepine derived from milk protein to support short-term anxiety relief
Increased Safety & Security
Time-Saving Convenience
Zylkene holds a best-in-class position for targeted separation and noise phobia support because it delivers a single, milk-derived peptide (alpha-casozepine) in a drug-free, easy-to-dose capsule that many owners find predictable for daily use. Compared with pheromone-based Adaptil and multi-ingredient chews, Zylkene’s simplicity reduces interactions with other medications and often provides a cost-effective option for long-term maintenance without the regulatory or quality-variability concerns sometimes seen with hemp/CBD products.
Milk-protein magic
Separation whisper
Vet-favorite calm
Contains alpha-casozepine derived from milk protein to support short-term anxiety relief
Non-drowsy formulation suitable for separation, travel, and acute noise events
Milk-protein magic
Separation whisper
Vet-favorite calm
Contains alpha-casozepine derived from milk protein to support short-term anxiety relief
Non-drowsy formulation suitable for separation, travel, and acute noise events
$30-60 USD
Adaptil Calm Tablets
Adaptil is the market leader for environmental calming thanks to decades of pheromone research and a broad product line that includes diffusers, collars and now oral formulations, giving households an economical way to manage home-based separation and noise triggers. Technically distinct from oral nutraceuticals like Zylkene or hemp chews, Adaptil’s pheromone approach complements those products—providing low-cost, continuous environmental coverage while owners use edible supplements for on-the-go or acute episodes.
Pheromone hug
Noise-ninja aid
Pheromone hug
Noise-ninja aid
Review Summary
"Adaptil Calm Tablets are frequently reported as helpful when used as part of a multi-modal plan (diffuser, training), but tablets alone often produce modest or inconsistent results."
Pocket-size peace
Veterinary-formulated tablet intended to support calm behavior during separation and noise triggers
Pocket-size peace
Veterinary-formulated tablet intended to support calm behavior during separation and noise triggers
Increased Safety & Security
Self-Improvement & Personal Growth
Adaptil is the market leader for environmental calming thanks to decades of pheromone research and a broad product line that includes diffusers, collars and now oral formulations, giving households an economical way to manage home-based separation and noise triggers. Technically distinct from oral nutraceuticals like Zylkene or hemp chews, Adaptil’s pheromone approach complements those products—providing low-cost, continuous environmental coverage while owners use edible supplements for on-the-go or acute episodes.
Pheromone hug
Noise-ninja aid
Pocket-size peace
Veterinary-formulated tablet intended to support calm behavior during separation and noise triggers
Designed to complement pheromone-based approaches and daily stress management
Pheromone hug
Noise-ninja aid
Pocket-size peace
Veterinary-formulated tablet intended to support calm behavior during separation and noise triggers
Designed to complement pheromone-based approaches and daily stress management
$35-65 USD
NaturVet Quiet Moments Calming Aid
NaturVet Quiet Moments is positioned as a budget-friendly, widely available calming aid that combines multiple calming nutrients to help dogs prone to separation anxiety and noise phobias, making it attractive for price-sensitive owners or multi-dog households. While it may not offer the single-ingredient specificity of Zylkene or the veterinary-grade formulation of VetriScience, its lower price point and retail ubiquity make it an accessible first-step option before investing in higher-cost or specialized therapies.
Herbal hush
Melatonin mellow
Herbal hush
Melatonin mellow
Review Summary
"Users like the taste and affordability of NaturVet Quiet Moments and find it offers mild, situational calming, but results are variable and it’s often less effective for intense separation or noise phobias."
Travel-ready calm
Soft chews with melatonin and gal-tryptophan to promote relaxation and sleep
Travel-ready calm
Soft chews with melatonin and gal-tryptophan to promote relaxation and sleep
Increased Safety & Security
Time-Saving Convenience
NaturVet Quiet Moments is positioned as a budget-friendly, widely available calming aid that combines multiple calming nutrients to help dogs prone to separation anxiety and noise phobias, making it attractive for price-sensitive owners or multi-dog households. While it may not offer the single-ingredient specificity of Zylkene or the veterinary-grade formulation of VetriScience, its lower price point and retail ubiquity make it an accessible first-step option before investing in higher-cost or specialized therapies.
Herbal hush
Melatonin mellow
Travel-ready calm
Soft chews with melatonin and gal-tryptophan to promote relaxation and sleep
Affordable option for daily support of separation stress and noise sensitivity
Herbal hush
Melatonin mellow
Travel-ready calm
Soft chews with melatonin and gal-tryptophan to promote relaxation and sleep
Affordable option for daily support of separation stress and noise sensitivity
$15-30 USD
VetriScience Composure Pro Chews
VetriScience Composure Pro Chews earn a market-leader reputation among veterinary-formulated options by combining clinically oriented nutrients in a palatable chew designed for faster onset and consistent dosing during acute separation or storm events. Though typically at a premium price versus mass-market brands like NaturVet, Composure Pro’s veterinary backing and targeted nutrient profile offer technical advantages for dogs who need a more robust, evidence-informed approach than single-ingredient or hemp-based alternatives.
Pro-grade zen
Training-friendly chew
Pro-grade zen
Training-friendly chew
Review Summary
"VetriScience Composure Pro Chews are commonly praised for producing consistent, noticeable reductions in situational anxiety and noise reactivity with good tolerability, though they are on the pricier side."
Clinic-tested calm
Proprietary calming complex combining casein-derived peptides and calming amino acids for stress reduction
Clinic-tested calm
Proprietary calming complex combining casein-derived peptides and calming amino acids for stress reduction
Increased Safety & Security
Skill Development & Mastery
Self-Improvement & Personal Growth
VetriScience Composure Pro Chews earn a market-leader reputation among veterinary-formulated options by combining clinically oriented nutrients in a palatable chew designed for faster onset and consistent dosing during acute separation or storm events. Though typically at a premium price versus mass-market brands like NaturVet, Composure Pro’s veterinary backing and targeted nutrient profile offer technical advantages for dogs who need a more robust, evidence-informed approach than single-ingredient or hemp-based alternatives.
Pro-grade zen
Training-friendly chew
Clinic-tested calm
Proprietary calming complex combining casein-derived peptides and calming amino acids for stress reduction
Formulated by veterinary supplement makers for situational and ongoing use (separation, storms, fireworks)
Pro-grade zen
Training-friendly chew
Clinic-tested calm
Proprietary calming complex combining casein-derived peptides and calming amino acids for stress reduction
Formulated by veterinary supplement makers for situational and ongoing use (separation, storms, fireworks)
$40-75 USD
ThunderWunders Hemp Dog Calming Chews
ThunderWunders offers a hemp-based calming chew that appeals to owners seeking cannabinoid-supported relaxation, which can engage different biochemical pathways than traditional nutraceuticals or pheromones and may be useful as part of a multimodal plan for separation and noise phobias. Financially and technically, hemp chews often sit mid-range in price and present a unique value proposition versus prescription meds—however buyers should weigh regulatory variability and pair them thoughtfully with pheromone (Adaptil) or veterinary options (VetriScience) for best results.
Hemp hug
Thunderproof chew
Hemp hug
Thunderproof chew
Review Summary
"ThunderWunders Hemp Dog Calming Chews receive mixed feedback — some owners report meaningful improvement in thunder/noise phobia, while others see little change; potency and batch variability are common concerns."
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Increased Safety & Security
Recreational Enjoyment
ThunderWunders offers a hemp-based calming chew that appeals to owners seeking cannabinoid-supported relaxation, which can engage different biochemical pathways than traditional nutraceuticals or pheromones and may be useful as part of a multimodal plan for separation and noise phobias. Financially and technically, hemp chews often sit mid-range in price and present a unique value proposition versus prescription meds—however buyers should weigh regulatory variability and pair them thoughtfully with pheromone (Adaptil) or veterinary options (VetriScience) for best results.
Hemp hug
Thunderproof chew
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Soft, palatable chews intended for rapid onset around stressful events like thunderstorms or fireworks
Hemp hug
Thunderproof chew
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Soft, palatable chews intended for rapid onset around stressful events like thunderstorms or fireworks
$30-60 USD